Study Finds Neofilera Dermal Filler Presents Lower Embolic Risk at Lower Injection Volumes in Rabbit Model
A bioRxiv preprint study tested the arterial embolism risk of Neofilera, a dermal filler composed of carboxymethyl cellulose and polylactic acid microspheres, by injecting it into rabbit arteries at different volumes and dilutions. The research found that 0.1 mL injections dispersed quickly without significant tissue damage, while 0.2 mL injections increased vascular occlusion risk even when diluted. The findings suggest injection volume is a critical factor in minimizing embolic complications from this filler type.
Researchers conducted an animal study to assess the embolic risk of Neofilera dermal filler by injecting it into the central auricular arteries of rabbits at volumes of 0.1 mL or 0.2 mL, with some samples diluted at ratios of 1:5, 1:10, and 1:15. They monitored for transparent emboli immediately after injection and evaluated tissue necrosis and histopathological changes at days 1 and 7 post-injection. The 0.1 mL dose dispersed within minutes and did not cause significant tissue necrosis at either observation point, whereas the 0.2 mL dose was associated with increased vascular occlusion even in diluted forms. The study concludes that Neofilera presents a lower embolic risk when administered at smaller volumes, with implications for safe clinical injection practices.
What's missing
The study's limitations include its use of a rabbit model, which may not fully translate to human vascular anatomy and physiology; the clinical relevance of these findings for human dermal filler injections; and whether results apply to subcutaneous or intradermal injection routes commonly used in aesthetic medicine rather than direct arterial injection.
What different sources said
- bioRxivCenter
Risk Assessment of Arterial Embolism from Neofilera(R) Filler in Rabbits
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